Williamson R C, Buchholtz T W, Malt R A
Gastroenterology. 1978 Aug;75(2):249-54.
Possible humoral involvement in the control of postresectional intestinal adaptation was tested in individual rats and in pairs of rats connected in vascular parabiosis for 48 hr. In individual rats, transection of the jejunum produced transient mucosal hyperplasia in the mid and distal small intestine, independent of the effect of laparotomy and of handling the bowel. Jejunal resection caused more intense and sustained distal hyperplasia, with increases in midbowel RNA content (38%), DNA content (16%), and DNA specific activity (68%) over values 48 hr after transection. In parabiotic rats, both transection and resection of the jejunum in one partner stimulated mucosal uptake of [H]TdR in the intact parabiont; increments of 59 to 128% in total radioactivity and in specific activity of DNA were found in the mid and distal small intestine of the intact parabiont. Because only rats actually undergoing abdominal operations had higher mucosal nucleic acid contents than their parabiotic partners, the transmitted response was weaker than the direct response. Systemic factors as well as local (topical) stimulators appear to be involved in adaptation of the shortened gut.
在个体大鼠以及通过血管联体共生连接48小时的成对大鼠中，对体液可能参与切除术后肠道适应性调控进行了测试。在个体大鼠中，空肠横断会在空肠中段和远端小肠产生短暂的黏膜增生，这与剖腹术及肠道操作的影响无关。空肠切除会导致更强烈且持续的远端增生，横断48小时后，肠中段RNA含量增加38%、DNA含量增加16%、DNA比活性增加68%。在联体共生大鼠中，联体一方的空肠横断和切除都会刺激完整联体大鼠的黏膜对[H]TdR的摄取；在完整联体大鼠的空肠中段和远端，发现总放射性及DNA比活性增加了59%至128%。由于只有实际接受腹部手术的大鼠的黏膜核酸含量高于其联体共生伙伴，所以传递的反应比直接反应弱。全身因素以及局部（局部）刺激物似乎都参与了短肠的适应性调节。
