Collins J A, So Y, Wilson E H, Wrixon W, Casper R F
Can Med Assoc J. 1984 Feb 1;130(3):269-73.
In a follow-up study of 1297 couples registered at a Nova Scotia infertility clinic with a complaint of infertility of at least 12 months' duration, the cumulative pregnancy rate at 36 months, with 95% confidence limits, was found to be 49 +/- 4%. The predictors of pregnancy by univariate analysis were a favourable primary clinical diagnosis (p less than 0.001), a duration of infertility of less than 3 years (p less than 0.001), a single diagnosis for the infertility (p less than 0.001), a previous pregnancy in the partnership (p = 0.001) and a length of marriage of less than 4 years (p = 0.002). Proportional hazards analysis confirmed these variables as predictors of pregnancy. The highest cumulative pregnancy rates after 12 and 36 months of follow-up were observed in cases of ovulation deficiency, and the lowest were seen in cases of tubal defects. However, before the process of diagnosing infertility begins, useful prognostic information can be determined from the length of marriage, the duration of infertility and the partnership's history of previous pregnancy.
在一项针对新斯科舍省一家不孕症诊所登记的1297对夫妇的随访研究中，这些夫妇均主诉不孕至少12个月，结果发现36个月时的累积妊娠率及95%置信区间为49±4%。单因素分析显示，妊娠的预测因素包括：首要临床诊断良好（p<0.001）、不孕时间少于3年（p<0.001）、单一不孕诊断（p<0.001）、伴侣双方既往有过妊娠（p = 0.001）以及结婚时间少于4年（p = 0.002）。多因素比例风险分析证实这些变量为妊娠的预测因素。随访12个月和36个月后，排卵功能不全患者的累积妊娠率最高，输卵管缺陷患者的累积妊娠率最低。然而，在开始不孕症诊断流程之前，可以根据结婚时长、不孕时间以及伴侣双方既往妊娠史来确定有用的预后信息。
