Lipnick R, Speizer F E, Bain C, Willett W, Rosner B, Stampfer M J, Belanger C, Hennekens C H
Cancer. 1984 Feb 15;53(4):1020-4. doi: 10.1002/1097-0142(19840215)53:4<1020::aid-cncr2820530433>3.0.co;2-g.
Among 714 premenopausal and 130 postmenopausal breast cancer cases matched with 8440 controls for age in years and menopausal status, risk indicators for breast cancer were similar, although most associations were stronger in the premenopausal women. Compared with nulliparous women, the relative risk (RR) for those with first birth before age 25 years was 0.7 (95% confidence limits [CL] from 0.5 to 0.9) among premenopausal women, and 0.7 (0.4-1.4) for postmenopausal women. In the premenopausal cases, a history of breast cancer in a sister gave a RR of 3.0 (2.1-4.1) and in a mother 1.9 (1.4-2.5), whereas for the postmenopausal women the RRs were 1.4 (0.6-3.1) and 1.3 (0.6-2.6), respectively. Fibrocystic breast disease was also a significant predictor of subsequent breast cancer in the premenopausal and postmenopausal women. In relation to women having a single birth, premenopausal women with six or more births had a risk of breast cancer of 0.6 (0.4-1.0), which was present even after adjustment for age at first birth.
在714例绝经前乳腺癌病例和130例绝经后乳腺癌病例中，这些病例按年龄和绝经状态与8440名对照进行匹配，乳腺癌的风险指标相似，尽管大多数关联在绝经前女性中更强。与未生育的女性相比，绝经前女性中首次生育年龄在25岁之前的女性的相对风险（RR）为0.7（95%置信区间[CL]为0.5至0.9），绝经后女性为0.7（0.4 - 1.4）。在绝经前病例中，姐妹有乳腺癌病史的RR为3.0（2.1 - 4.1），母亲有乳腺癌病史的RR为1.9（1.4 - 2.5），而绝经后女性的RR分别为1.4（0.6 - 3.1）和1.3（0.6 - 2.6）。纤维囊性乳腺病也是绝经前和绝经后女性后续患乳腺癌的重要预测因素。与只生育一次的女性相比，生育六次或更多次的绝经前女性患乳腺癌的风险为0.6（0.4 - 1.0），即使在调整首次生育年龄后该风险依然存在。
