复发性恶性黑色素瘤的系列细胞遗传学分析

Serial cytogenetic analysis of a recurrent malignant melanoma.

作者信息

Ochi H, Wake N, Rao U, Takeuchi J, Slocum H K, Rustum Y M, Karakousis C, Sandberg A A

出版信息

Cancer Genet Cytogenet. 1984 Feb;11(2):175-83. doi: 10.1016/0165-4608(84)90112-2.

Abstract

A metastatic malignant melanoma in a 54-yr-old white female was examined cytogenetically on three different occasions. We found two different clones, one hypodiploid and another hypertriploid; however, both clones had the same markers [i.e., der(6),t(6;17), and der(17),t(1;17)]. Detailed analysis of the histopathology and clinical course suggests that these two different clones reflected different morphology and results of therapy.

摘要

对一名54岁白人女性的转移性恶性黑色素瘤在三个不同时间点进行了细胞遗传学检查。我们发现了两个不同的克隆，一个亚二倍体和另一个超三倍体；然而，两个克隆都有相同的标记（即der(6)、t(6;17)和der(17)、t(1;17)）。对组织病理学和临床病程的详细分析表明，这两个不同的克隆反映了不同的形态和治疗结果。