Riddle D L, Brenner S
Genetics. 1978 Jun;89(2):299-314. doi: 10.1093/genetics/89.2.299.
Two cases of indirect suppression have been characterized. One case involves suppressors compensating for defects in muscle structure. Nine independent suppressor mutations were judged to lie in a single suppressor gene, sup-3. Suppression is dominant, but dose dependent, and results in improved locomotion, as well as in an increase in the ability of mutant animals to lay eggs. Mutations in six genes known to affect muscle structure were tested for suppression by representative sup-3 mutations. Alleles of three of the six genes are suppressed, two of which are known to code for thick filament proteins. One suppressor allele was identified as a deletion by genetic criteria. A second case of indirect suppression is not associated with muscle defects, but involves two mutant genes producing uncoordinated phenotypes very similar to one another. As in the first case, suppression is dominant but dose dependent and is not allele specific.
已对两例间接抑制现象进行了特征描述。其中一例涉及抑制基因补偿肌肉结构缺陷。九个独立的抑制基因突变被判定位于单个抑制基因sup-3中。抑制作用是显性的，但具有剂量依赖性，会使运动能力得到改善，同时突变动物产卵能力也会增强。对六个已知影响肌肉结构的基因的突变进行了测试，以检测代表性的sup-3突变对其的抑制作用。六个基因中的三个基因的等位基因受到抑制，其中两个已知编码粗丝蛋白。通过遗传学标准确定一个抑制等位基因为缺失。另一例间接抑制现象与肌肉缺陷无关，而是涉及两个产生非常相似不协调表型的突变基因。与第一例一样，抑制作用是显性的但具有剂量依赖性，且不具有等位基因特异性。
