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一种肌肉突变体的显性抑制因子确定了秀丽隐杆线虫的一个必需基因。

Dominant suppressors of a muscle mutant define an essential gene of Caenorhabditis elegans.

作者信息

Greenwald I S, Horvitz H R

出版信息

Genetics. 1982 Jun;101(2):211-25. doi: 10.1093/genetics/101.2.211.

Abstract

The sup-11 1 locus of C. elegans was defined by rare dominant suppressors of unc-93(e1500) III, a mutation that affects muscle structure. All ten of these dominant suppressors have a recessive "scrawny" phenotype. Two additional classes of sup-11 alleles were identified. One class, null alleles, was obtained by reversion of the dominant suppressor activity. These null alleles are recessive embryonic lethals, indicating that sup-11 is an essential gene. Members of the second class, rare semidominant revertants of the "scrawny" phenotype, are partial suppressors of unc-93(e1500). The genetic properties of the dominant suppressor mutations suggest that they are rare missense mutations that confer a novel activity to the sup-11 protein. We consider some of the ways that sup-11 alleles might suppress unc-93(e1500), including the possibilities that the altered sup-11 proteins restore function to a protein complex or are modified products of a gene that is a member of an unc-93 gene family.

摘要

秀丽隐杆线虫的sup-11 1基因座由unc-93(e1500) III的罕见显性抑制子定义,unc-93(e1500) III是一个影响肌肉结构的突变。所有这十个显性抑制子都具有隐性的“瘦骨嶙峋”表型。另外还鉴定出了两类sup-11等位基因。一类是无效等位基因,通过显性抑制子活性的回复突变获得。这些无效等位基因是隐性胚胎致死基因,表明sup-11是一个必需基因。第二类的成员,即“瘦骨嶙峋”表型的罕见半显性回复突变体,是unc-93(e1500)的部分抑制子。显性抑制子突变的遗传特性表明它们是罕见的错义突变,赋予了sup-11蛋白一种新活性。我们考虑了sup-11等位基因可能抑制unc-93(e1500)的一些方式,包括改变后的sup-11蛋白恢复蛋白复合物功能的可能性,或者是unc-93基因家族成员基因的修饰产物。

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