Waterston R H, Brenner S
Nature. 1978 Oct 26;275(5682):715-9. doi: 10.1038/275715a0.
A suppressor mutation has been isolated in Caenorhabditis elegans through reversion analysis of a muscle-defective mutant. The suppressor mutation acts on specific alleles of at least six genes and in one case we have been able to show that it partially restores functional gene product to a mutant otherwise lacking that product. These and other features of the suppressor suggest that it acts at some step in information transfer, perhaps through mechanisms similar to those described previously in microorganisms.
通过对一个肌肉缺陷型突变体进行回复突变分析，在秀丽隐杆线虫中分离出了一个抑制突变。该抑制突变作用于至少六个基因的特定等位基因，在一个案例中，我们已经能够证明它能部分恢复一个原本缺乏该产物的突变体的功能性基因产物。抑制突变的这些及其他特征表明，它在信息传递的某个步骤起作用，可能是通过类似于先前在微生物中描述的机制。
