Sharifi J, Ghavami F
Clin Pediatr (Phila). 1984 Feb;23(2):87-90. doi: 10.1177/000992288402300204.
In 1980, 104 infants with seven to 15 percent dehydration due to severe diarrhea and vomiting were hospitalized in Tehran and treated in two separate phases, deficit therapy and maintenance therapy, using two isotonic oral solutions. For deficit therapy, solution A (sodium 80, potassium 20 mmol/l) was administered at a rate of 40 ml/kg per hour until all signs of dehydration disappeared. For maintenance therapy, solution B (sodium 40, potassium 30 mmol/l) was given sip by sip at a rate of about 250 ml/kg per 24 hours until diarrhea stopped. Intravenous fluids were not used, even in severe dehydration and shock. The efficacy and safety of this regimen were confirmed by rapid and successful rehydration and correction of electrolyte abnormalities present on admission.
1980年，德黑兰收治了104名因严重腹泻和呕吐导致7%至15%脱水的婴儿，并分两个阶段进行治疗，即缺量疗法和维持疗法，使用两种等渗口服溶液。缺量疗法阶段，给予溶液A（钠80、钾20毫摩尔/升），以每小时40毫升/千克的速度给药，直至脱水症状全部消失。维持疗法阶段，给予溶液B（钠40、钾30毫摩尔/升），以每24小时约250毫升/千克的速度逐口喂服，直至腹泻停止。即使在严重脱水和休克的情况下也未使用静脉输液。入院时存在的电解质异常通过快速且成功的补液得以纠正，从而证实了该治疗方案的有效性和安全性。
