下丘脑-免疫相互作用。垂体切除术对神经免疫调节的影响。

Hypothalamic-immune interactions. Effect of hypophysectomy on neuroimmunomodulation.

作者信息

Cross R J, Brooks W H, Roszman T L, Markesbery W R

出版信息

J Neurol Sci. 1982 Mar;53(3):557-66. doi: 10.1016/0022-510x(82)90250-7.

Abstract

Electrolyte destruction of certain nuclei of the brain cause specific structural and functional changes in the immune system. Lesions in the preoptic-anterior hypothalamic area result in thymic involution and a decrease in the number and blastogenic reactivity of splenocytes. In contrast, lesions in the hippocampus increase thymic and splenic mitogenic responsiveness and cellularity. Hypophysectomy abrogates all changes in splenocyte number and function induced by hypothalamic and limbic lesions. The effects of ablating the hippocampus and amygdaloid complex on thymocyte number and function also are abolished. Hypothalamic lesions in hypophysectomized animals result in an increase in the number of thymocytes but suppressed mitogenic activity. These data indicated that neuroimmunomodulation is mediated predominantly but not exclusively by the pituitary gland.

摘要

对大脑某些核团的电解质破坏会导致免疫系统发生特定的结构和功能变化。视前区-下丘脑前部区域的损伤会导致胸腺萎缩以及脾细胞数量和增殖反应性降低。相反，海马体损伤会增加胸腺和脾脏的有丝分裂反应性及细胞数量。垂体切除可消除下丘脑和边缘系统损伤所诱导的脾细胞数量和功能的所有变化。切除海马体和杏仁复合体对胸腺细胞数量和功能的影响也会被消除。垂体切除动物的下丘脑损伤会导致胸腺细胞数量增加，但有丝分裂活性受到抑制。这些数据表明，神经免疫调节主要但并非仅由垂体介导。