Homma I, Obata T, Sibuya M, Uchida M
J Appl Physiol Respir Environ Exerc Physiol. 1984 Jan;56(1):8-11. doi: 10.1152/jappl.1984.56.1.8.
The effects of bilateral alternating out-of-phase vibrations were studied in 10 normal healthy subjects and five asthmatic patients. The second or third intercostal spaces were vibrated during expiration, and the seventh to ninth intercostal spaces were vibrated during inspiration. Most subjects sensed breathlessness during such vibrations, and 100 Hz was most effective. The degree of breathlessness correlated positively with increased respiratory rate. Respiratory rate increased from 14.1 +/- 3.78 (mean +/- SD) to 22.3 +/- 7.14 breaths/min (P less than 0.05) during relatively severe breathlessness and to 20.39 +/- 5.66 breaths/min (P less than 0.05) during less uncomfortable sensation. Slight or negligible breathlessness induced no significant increase in rate (15.33 +/- 4.19 breaths/min). All asthma patients described the sensations during vibration as similar to those during asthma attacks, and their respiratory rates increased 20.7 +/- 11.03% during 100 Hz vibration (P less than 0.01). It is suggested that the uncomfortable sensation of breathlessness may be induced by muscle spindles in the intercostal muscles being activated out of phase with the respiratory cycle. The central mechanism that receives the intercostal afferents may have a certain gate that operates in relation to the sensation of breathlessness.
对10名正常健康受试者和5名哮喘患者研究了双侧交替异相振动的影响。在呼气时振动第二或第三肋间间隙，在吸气时振动第七至第九肋间间隙。大多数受试者在这种振动期间感到呼吸困难，且100赫兹最为有效。呼吸困难程度与呼吸频率增加呈正相关。在相对严重的呼吸困难期间，呼吸频率从14.1±3.78（平均值±标准差）次/分钟增加到22.3±7.14次/分钟（P<0.05），在不太舒适的感觉期间增加到20.39±5.66次/分钟（P<0.05）。轻微或可忽略不计的呼吸困难不会导致呼吸频率显著增加（15.33±4.19次/分钟）。所有哮喘患者描述振动期间的感觉与哮喘发作期间相似，且在100赫兹振动期间他们的呼吸频率增加了20.7±11.03%（P<0.01）。提示呼吸困难的不适感可能是由肋间肌中的肌梭与呼吸周期不同步激活所致。接收肋间传入神经的中枢机制可能有一个与呼吸困难感觉相关的特定闸门。
