Edo H, Kimura H, Niijima M, Sakabe H, Shibuya M, Kanamaru A, Homma I, Kuriyama T
Department of Chest Medicine, School of Medicine, Chiba University, Japan.
J Appl Physiol (1985). 1998 May;84(5):1487-91. doi: 10.1152/jappl.1998.84.5.1487.
Vibratory stimulation applied to the chest wall during inspiration reduces the intensity of breathlessness, whereas the same stimulation during expiration has no effect or may increase breathlessness. The purpose of the present study was to determine whether vibration reduced the intensity of breathlessness during progressive hypercapnia with and without the addition of an external resistive load. A second objective was to see whether the mouth occlusion pressure at 0.2 s (P0.2) was reduced by the vibratory stimulation. Hypercapnic ventilatory response was conducted in 10 healthy male volunteers with simultaneous measurement of visual analog scale, P0.2, and minute ventilation. Hypercapnic ventilatory response was performed and randomly combined with or without vibratory stimulation (100 Hz) as well as with or without inspiratory load. With inspiratory load, in-phase vibration did not cause any significant changes in the slopes of P0.2 and minute ventilation to CO2, whereas the slope of visual analog scale to CO2 significantly decreased from 0.47 +/- 0.15 to 0.34 +/- 0.11 (SE) cm/Torr (P < 0.05). We conclude that in-phase vibration could decrease the slope of breathlessness elicited by inspiratory load combined with hypercapnia without changing motor output.
吸气时对胸壁施加振动刺激可降低呼吸困难的强度，而呼气时施加相同刺激则无效果或可能加重呼吸困难。本研究的目的是确定在有或无外部阻力负荷的情况下，振动是否能降低进行性高碳酸血症期间呼吸困难的强度。第二个目的是观察振动刺激是否能降低0.2秒时的口腔闭合压（P0.2）。对10名健康男性志愿者进行了高碳酸通气反应试验，同时测量视觉模拟评分、P0.2和分钟通气量。进行高碳酸通气反应，并随机组合有或无振动刺激（100赫兹）以及有或无吸气负荷的情况。有吸气负荷时，同相振动对P0.2和分钟通气量对二氧化碳的斜率没有引起任何显著变化，而视觉模拟评分对二氧化碳的斜率从0.47±0.15显著降至0.34±0.11（标准误）厘米/托（P<0.05）。我们得出结论，同相振动可降低吸气负荷联合高碳酸血症引起的呼吸困难斜率，而不改变运动输出。
