Allansmith M R, Baird R S, Greiner J V, Bloch K J
J Allergy Clin Immunol. 1984 Jan;73(1 Pt 1):49-55. doi: 10.1016/0091-6749(84)90483-4.
We assessed whether anaphylactic stimulation of rat ocular tissue produces a late-phase reaction at the histologic level. Clinical changes of swelling and redness started within minutes, peaked at about 20 min, and then subsided. Neutrophils increased at 1/2 hr after stimulation, peaked at 6 hr, and subsided to normal at 24 hr. Eosinophils reached a significant increase at 6 hr. Compaction of vessel contents was present at 1/2 hr; vessels were normal thereafter. Extravasated red blood cells and debris in the tissue were prominent at 6 hr. Macrophages had accumulated significantly at 6 hr and maintained that level at 24 hr. Any effect of anaphylaxis on macrophage accumulation was masked because control-injected ocular tissue also showed an accumulation of macrophages at 24 hr. Our results demonstrate that in ocular tissue, as in skin, the early acute phase of immediate hypersensitivity is but one stage of a multiphasic reaction.
我们评估了对大鼠眼部组织进行过敏刺激是否会在组织学水平上产生迟发性反应。肿胀和发红的临床变化在数分钟内开始，在约20分钟时达到峰值，然后消退。中性粒细胞在刺激后半小时增加，在6小时时达到峰值，并在24小时时恢复正常。嗜酸性粒细胞在6小时时显著增加。血管内容物在半小时时出现浓缩，此后血管恢复正常。组织中的红细胞外渗和碎片在6小时时很明显。巨噬细胞在6小时时显著积聚，并在24小时时维持该水平。由于注射对照的眼部组织在24小时时也显示出巨噬细胞的积聚，过敏反应对巨噬细胞积聚的任何影响都被掩盖了。我们的结果表明，在眼部组织中，与皮肤一样，速发型超敏反应的早期急性期只是多相反应的一个阶段。
