Tachibana H, Meyer J S, Kitagawa Y, Rogers R L, Okayasu H, Mortel K F
J Am Geriatr Soc. 1984 Feb;32(2):114-20. doi: 10.1111/j.1532-5415.1984.tb05850.x.
Regional cerebral blood flow values were measured utilizing the 133Xe inhalation method in patients with multi-infarct dementia (MID) (n = 22, age 67.4 +/- 9.8 years), in patients with senile dementia of Alzheimer type (SDAT) (n = 36, age 63.8 +/- 8.0) and in age-matched normal healthy volunteers (n = 50, age 67.5 +/- 9.3). Mean hemispheric gray matter flow values were significantly reduced in MID (P less than 0.01) and SDAT (P less than 0.01) patients compared with age-matched normal volunteers. In normal volunteers, mean flow values showed gradual declines with advancing age (r = -0.44, P less than 0.005). In MID patients there were significant decreases in flow values with advancing age (r = -0.43, P less than 0.05), but flow values were consistently lower than in age-matched normals. Reductions of flow were most evident in the distribution of both middle cerebral arteries. Unlike MID patients, patients with SDAT had diffusely reduced flow values over all age ranges without correlation with advancing age. Reductions of mean flow values in both dementia groups were significantly correlated with severity of dementia (P less than 0.05 for both groups). Cerebral blood flow reductions related to the aging process also contribute to decreased cerebral perfusion in patients with MID. This is not true in SDAT, where the disease process itself pre-empts cerebral blood flow reductions attributable to aging.
采用氙-133吸入法测量了多发梗死性痴呆（MID）患者（n = 22，年龄67.4±9.8岁）、阿尔茨海默型老年性痴呆（SDAT）患者（n = 36，年龄63.8±8.0岁）以及年龄匹配的正常健康志愿者（n = 50，年龄67.5±9.3岁）的局部脑血流量值。与年龄匹配的正常志愿者相比，MID患者（P<0.01）和SDAT患者（P<0.01）的平均半球灰质血流量值显著降低。在正常志愿者中，平均血流量值随年龄增长逐渐下降（r = -0.44，P<0.005）。在MID患者中，血流量值也随年龄增长显著下降（r = -0.43，P<0.05），但血流量值始终低于年龄匹配的正常人。血流量减少在大脑中动脉分布区域最为明显。与MID患者不同，SDAT患者在所有年龄范围内血流量值均普遍降低，且与年龄增长无关。两个痴呆组的平均血流量值降低均与痴呆严重程度显著相关（两组P均<0.05）。与衰老过程相关的脑血流量减少也导致了MID患者脑灌注的降低。但在SDAT患者中并非如此，在SDAT患者中，疾病过程本身先于因衰老导致的脑血流量减少。
