Lee E J
Ann Acad Med Singap. 1987 Jan;16(1):128-32.
Adverse drug reactions not only occur more frequently but are also of a more severe nature in the elderly. For warfarin and many of the psychoactive drugs, this is due mainly to an increased pharmacodynamic sensitivity to the actions of these drugs. For a number of other drugs, old age is associated with changes in their distribution and eventual elimination from the body. This increases the risk of a relative overdose during routine use of the drug. Such risks can be minimised by the judicious adjustment of the dosages of these drugs.
药物不良反应在老年人中不仅发生得更频繁，而且性质更严重。对于华法林和许多精神活性药物来说，这主要是由于对这些药物作用的药效学敏感性增加。对于许多其他药物，老年与它们在体内的分布变化以及最终从体内消除有关。这增加了在常规使用药物期间相对过量用药的风险。通过明智地调整这些药物的剂量，可以将此类风险降至最低。
