Granneman J G, Campbell R G
Metabolism. 1984 Mar;33(3):257-61. doi: 10.1016/0026-0495(84)90047-7.
Rats were fed standard laboratory chow or sucrose + chow for 2-3 weeks. Sucrose feeding significantly increased the size and norepinephrine content of interscapular brown adipose tissue (BAT). Sucrose feeding stimulated in vivo lipogenesis in BAT, white adipose tissue, and liver. Unilateral denervation reduced BAT norepinephrine content by 90%, and significantly reduced BAT protein and DNA content. Prior surgical denervation of BAT had no effect on lipogenesis in chow-fed rats, but reduced the sucrose-induced lipogenesis in BAT by 75% and increased lipogenesis in retroperitoneal white adipose tissue of sucrose-fed rats. These data demonstrate that the optimal stimulation of lipogenesis in BAT by sucrose feeding requires innervation of this tissue.
将大鼠喂食标准实验室饲料或蔗糖加饲料2至3周。喂食蔗糖显著增加了肩胛间棕色脂肪组织（BAT）的大小和去甲肾上腺素含量。喂食蔗糖刺激了BAT、白色脂肪组织和肝脏中的体内脂肪生成。单侧去神经支配使BAT去甲肾上腺素含量降低了90%，并显著降低了BAT的蛋白质和DNA含量。先前对BAT进行手术去神经支配对喂食普通饲料的大鼠的脂肪生成没有影响，但使喂食蔗糖的大鼠BAT中蔗糖诱导的脂肪生成减少了75%，并增加了喂食蔗糖的大鼠腹膜后白色脂肪组织中的脂肪生成。这些数据表明，喂食蔗糖对BAT中脂肪生成的最佳刺激需要该组织的神经支配。
