Barry B W, El Eini D I
J Pharm Pharmacol. 1976 Mar;28(3):210-8. doi: 10.1111/j.2042-7158.1976.tb04133.x.
Solubility and dialysis methods were used to study the solubilization of hydrocortisone, dexamethasone, testosterone and progesterone in aqueous long-chain polyoxyethylene non-ionic surfactant solutions. Partition coefficients, Km, between micellar and aqueous phases were calculated between 10-50 degrees. Km decreased with temperature and polyoxyethylene chain length but increased with decrease in steroid polarity. The standard free energy change, deltaGOS, for the solubilization of the steroids decreased with decrease in steroid polarity and surfactant hydrophilic chain length but was essentially independent of temperature. The enthalpies and entropies for the process were determined from the variation of Km with temperature. deltaHOS and deltaSOS increased with decreasing steroid polarity but were essentially independent of temperature and polyoxyethylene chain length.
采用溶解度和透析方法研究了氢化可的松、地塞米松、睾酮和孕酮在长链聚氧乙烯非离子表面活性剂水溶液中的增溶作用。计算了10至50摄氏度之间胶束相和水相之间的分配系数Km。Km随温度和聚氧乙烯链长度的增加而降低，但随甾体极性的降低而增加。甾体增溶的标准自由能变化ΔGOS随甾体极性和表面活性剂亲水链长度的降低而降低，但基本上与温度无关。该过程的焓和熵由Km随温度的变化确定。ΔHOS和ΔSOS随甾体极性的降低而增加，但基本上与温度和聚氧乙烯链长度无关。
