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基于丁香花蕾精油的纳米乳液体系的抗癌和抗菌作用。

Anticancer and antibacterial effects of a clove bud essential oil-based nanoscale emulsion system.

机构信息

Department of Chemical Engineering, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.

Department of Biotechnology, Bhupat and Jyoti Mehta School of Biosciences, Indian Institute of Technology Madras, Chennai 600036, Tamil Nadu, India.

出版信息

Int J Nanomedicine. 2019 Aug 12;14:6439-6450. doi: 10.2147/IJN.S211047. eCollection 2019.

DOI:10.2147/IJN.S211047
PMID:31496696
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6697666/
Abstract

BACKGROUND AND PURPOSE

The essential oil derived from clove buds ( has been used as a chemopreventive agent in Ayurvedic medicine. The antiviral, antibacterial, and anticancer properties of its chemo-skeleton have motivated this study to explore its efficacy in pharmaceutics.

METHODS

Nanoscale-based emulsions were prepared by employing a spontaneous emulsification technique through self-assembly using varying concentrations of Tween 20 and Tween 80 surfactants. Their physicochemical properties and stability were studied in order to choose an optimum formulation which was clear and stable. The cytotoxicity of the stable oil-based emulsion system was evaluated using MTT assay, colony formation assay, and Annexin V-FITC assay against the thyroid cancer cell line (HTh-7).

RESULTS

All three methods verified apoptosis and reduction in cancer cell proliferation, making the formulation a promising candidate as an alternative cancer drug. The oil-based emulsion system was also tested for its antibacterial properties against . Membrane permeability studies proved its efficacy to permeate through cell membrane, thereby increasing the leakage of cytoplasmic contents.

CONCLUSION

Many current treatments for cancers are aggressive yet ineffective. This study positions the clove bud-based nanoscale emulsion as a suitable candidate for further in vivo studies and trials as a cancer drug.

摘要

背景与目的

丁香花蕾中提取的精油（）已被用作阿育吠陀医学中的化学预防剂。其化学骨架具有抗病毒、抗菌和抗癌特性，这促使本研究探索其在药剂学中的功效。

方法

通过自组装使用不同浓度的吐温 20 和吐温 80 表面活性剂，采用自发乳化技术制备基于纳米的乳液。研究了它们的物理化学性质和稳定性，以选择一种清晰稳定的最佳配方。使用 MTT 测定法、集落形成测定法和 Annexin V-FITC 测定法评估稳定油基乳液系统对甲状腺癌细胞系（HTh-7）的细胞毒性。

结果

这三种方法都验证了细胞凋亡和癌细胞增殖减少，使该制剂成为一种有前途的替代癌症药物的候选物。还测试了油基乳液系统对 的抗菌性能。膜通透性研究证明其能够穿透细胞膜，从而增加细胞质内容物的渗漏。

结论

许多当前的癌症治疗方法具有侵袭性但效果不佳。本研究将基于丁香花蕾的纳米乳液定位为进一步进行体内研究和临床试验作为癌症药物的合适候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6b21/6697666/55f7104035e9/IJN-14-6439-g0011.jpg
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