Bernstein A, Harris B
Am J Obstet Gynecol. 1984 Feb 1;148(3):309-12. doi: 10.1016/s0002-9378(84)80074-5.
Sexually active women with colposcopically directed, biopsy-proved cervical intraepithelial neoplasia were matched with normal control subjects with regard to age, race, and socioeconomic status, in order to determine if dietary and serum vitamin A (retinol) levels can be considered one of the contributing risk factors for the development of this disease process. An evaluation of women in the group with cervical intraepithelial neoplasia statistically showed lower levels of serum vitamin A (p = 0.1), although, dietary profiles of both groups did not yield a statistically significant difference (p = 0.7). These results suggest that low serum levels of vitamin A may be associated with the development of cervical intraepithelial neoplasia.
为了确定饮食和血清维生素A（视黄醇）水平是否可被视为导致这种疾病发生的风险因素之一，对阴道镜引导下活检证实为宫颈上皮内瘤变的性活跃女性，按照年龄、种族和社会经济地位与正常对照受试者进行匹配。对宫颈上皮内瘤变组女性的评估在统计学上显示血清维生素A水平较低（p = 0.1），不过，两组的饮食状况在统计学上没有显著差异（p = 0.7）。这些结果表明，血清维生素A水平低可能与宫颈上皮内瘤变的发生有关。
