Schneider A, Shah K
Department of Obstetrics and Gynecology, University of Ulm, FRG.
Arch Gynecol Obstet. 1989;246(1):1-13. doi: 10.1007/BF00933072.
Diet may act as a cofactor in the development of cancer of the cervix. A consistent correlation exists between low tissue concentrations, low serum level, and low intake of vitamin A, beta-carotene, vitamin C, or folic acid and an increased prevalence of cervical neoplasia. A moderate effect is seen in clinical trials with vitamin treatment of cervical intraepithelial neoplasias. The studies reviewed here were not consistent especially in the choice of controls and methods for the assessment of dietary and confounding factors. Proper morphologic identification of cervical intraepithelial neoplasia was not always achieved. Longitudinal and prospective cohort studies using more reliable methods for diet monitoring may be valuable for future research in this field.
饮食可能是宫颈癌发生发展中的一个辅助因素。组织中维生素A、β-胡萝卜素、维生素C或叶酸浓度低、血清水平低以及摄入量低与宫颈肿瘤患病率增加之间存在一致的相关性。在对宫颈上皮内瘤变进行维生素治疗的临床试验中观察到了适度的效果。此处综述的研究并不一致，尤其是在对照的选择以及饮食和混杂因素评估方法方面。并非总能对宫颈上皮内瘤变进行恰当的形态学鉴定。采用更可靠的饮食监测方法进行纵向和前瞻性队列研究可能对该领域未来的研究有价值。
