Shimizu H, Nagata C, Komatsu S, Morita N, Higashiiwai H, Sugahara N, Hisamichi S
Department of Public Health, Gifu University, School of Medicine, Japan.
Br J Cancer. 1996 Jun;73(12):1600-4. doi: 10.1038/bjc.1996.301.
To examine the relationship of dietary and serum vitamin A to the risk of cervical dysplasia, a case-control study was conducted in Miyagi, Japan. Cases were 137 women who were found by Papanicolaou test screening and histological examination provided by Miyagi Cancer Society between October 1987 and September 1988 to have cervical dysplasia. Controls were selected from participants of the general health examination provided by the Society and individually matched to cases on age and screening date. The consumption of retinol or carotene-rich foods during the past 7 days was assessed at interview. Information was also collected about other risk factors of cervical dysplasia, such as reproductive histories and sexual behaviour. The mean serum retinol levels were significantly lower among cases compared with controls, although dietary intake levels of retinol and carotene were not different between the two groups. When examined by tertile, the risk of cervical dysplasia was significantly higher among women in the highest tertile of dietary vitamin A level. An inverse association was observed between serum retinol level and risk of cervical dysplasia, although it did not achieve statistical significance.
为研究膳食及血清维生素A与宫颈发育异常风险之间的关系，在日本宫城县开展了一项病例对照研究。病例为1987年10月至1988年9月期间通过巴氏试验筛查并经宫城癌症协会组织的组织学检查确诊为宫颈发育异常的137名女性。对照选自该协会提供的一般健康检查参与者，并按年龄和筛查日期与病例进行个体匹配。通过访谈评估过去7天内视黄醇或富含胡萝卜素食物的摄入量。还收集了有关宫颈发育异常的其他风险因素的信息，如生殖史和性行为。病例组的血清视黄醇平均水平显著低于对照组，尽管两组之间视黄醇和胡萝卜素的膳食摄入量并无差异。按三分位数进行分析时，膳食维生素A水平处于最高三分位数的女性患宫颈发育异常的风险显著更高。血清视黄醇水平与宫颈发育异常风险之间存在负相关，尽管未达到统计学显著性。
