Fraunfelder F T, Zacarian S A, Wingfield D L, Limmer B L
Am J Ophthalmol. 1984 Feb;97(2):184-8. doi: 10.1016/s0002-9394(14)76088-x.
A total of 164 nodular and infiltrative eyelid basal cell carcinomas were treated with liquid nitrogen spray cryotherapy and followed up for a minimum of five years. For lesions less than 10 mm in diameter, nodular basal cell carcinomas had a 97% cure rate with cryotherapy and infiltrative basal cell carcinomas had a 94% cure rate. However, nodular of infiltrative basal cell carcinoma lesions larger than 10 mm in diameter had 85% and 82% cure rates with cryotherapy, respectively. After a minimum four-year follow-up period, 25 recurrent basal cell carcinomas previously treated by various methods had a 93% cure rate when re-treated with cryotherapy. Data for other malignant eyelid lesions treated with cryotherapy were insufficient for statistical analysis.
总共164例结节性和浸润性眼睑基底细胞癌接受了液氮喷雾冷冻治疗，并进行了至少五年的随访。对于直径小于10毫米的病变，结节性基底细胞癌冷冻治疗的治愈率为97%，浸润性基底细胞癌的治愈率为94%。然而，直径大于10毫米的结节性和浸润性基底细胞癌病变冷冻治疗的治愈率分别为85%和82%。在至少四年的随访期后，25例先前接受过各种治疗方法的复发性基底细胞癌再次接受冷冻治疗时，治愈率为93%。用冷冻治疗其他恶性眼睑病变的数据不足以进行统计分析。
