Tuppurainen K
Department of Ophthalmology, University Hospital of Kuopio, Finland.
Graefes Arch Clin Exp Ophthalmol. 1995 Apr;233(4):205-8. doi: 10.1007/BF00183593.
Basal cell carcinoma (BCC) is the most common of all malignant tumours and often appears on the periocular skin. In the present study, patients with 166 eyelid and periocular BCCs were treated with cryotherapy at the Eye Clinic of the Kuopio University Hospital. Seven patients with a total of eight BCCs died during the first year after cryotherapy, of causes unrelated to BCC. These cases were excluded from the analysis of outcome.
The tumours were photographed before excisional biopsy and histopathological examination. The BCCs were frozen twice with liquid nitrogen in a closed cryoprobe; a tissue thermometer was used.
During the mean follow-up of 5 years for 158 BCCs, recurrences were observed in 12 cases (7.6%). The most important prognostic factors for recurrence were large tumour size (maximum diameter exceeding 10 mm), tumour extension into the lid margin, and cicatrising (morpheaform) BCC. The complications of cryotherapy were slight, but in some cases lid ectropion needed surgical correction. The functional and cosmetic results were very satisfactory in most cases.
Ninety-two percent of BBCs treated with cryotherapy did not recur during mean follow-up of 5.0 years (range 1.6-8.4 years).
基底细胞癌（BCC）是所有恶性肿瘤中最常见的一种，常出现在眼周皮肤。在本研究中，库奥皮奥大学医院眼科诊所对166例眼睑及眼周基底细胞癌患者进行了冷冻治疗。7例患者共8处基底细胞癌在冷冻治疗后的第一年因与基底细胞癌无关的原因死亡。这些病例被排除在疗效分析之外。
在切除活检和组织病理学检查前对肿瘤进行拍照。使用封闭的冷冻探头将基底细胞癌用液氮冷冻两次；使用了组织温度计。
对158处基底细胞癌平均随访5年期间，12例（7.6%）出现复发。复发的最重要预后因素是肿瘤体积大（最大直径超过10毫米）、肿瘤延伸至睑缘以及瘢痕性（硬斑病样）基底细胞癌。冷冻治疗的并发症轻微，但在某些情况下睑外翻需要手术矫正。大多数情况下功能和美容效果非常令人满意。
在平均5.0年（范围1.6 - 8.4年）的随访期间，接受冷冻治疗的基底细胞癌中有92%未复发。
