Gottlieb M E, Stratton H H, Newell J C, Shah D M
Arch Surg. 1984 Mar;119(3):264-8. doi: 10.1001/archsurg.1984.01390150006002.
To evaluate hepatic function, the kinetics of indocyanine green clearance were studied in seven injured patients with hepatic venous catheters. Indocyanine green clearance after a bolus injection of 20 mg was relatively monoexponential on the first day after injury. Following this, a second slower compartment of indocyanine green clearance was uniformly evident, becoming most prominent around the fourth day after injury. Indocyanine green clearance again became more uniform as recovery continued. Fractional indocyanine green extraction ten minutes after injection decreased from 0.9 on the first day after injury to 0.2 three days later, and then returned to 0.7 on the seventh day after injury. These decreases in indocyanine green clearance preceded an increase in total serum bilirubin concentration to a mean value of 1.9 mg/dL. Indocyanine green clearance was thus found to be an early and sensitive indicator of impaired hepatic function.
为评估肝功能，对7例置有肝静脉导管的受伤患者进行了吲哚菁绿清除动力学研究。在受伤后的第一天，静脉推注20mg吲哚菁绿后的清除相对呈单指数形式。在此之后，吲哚菁绿清除的第二个较慢的部分始终明显，在受伤后约第四天最为显著。随着恢复的继续，吲哚菁绿清除再次变得更加均匀。注射后十分钟的吲哚菁绿分数提取率从受伤后第一天的0.9降至三天后的0.2，然后在受伤后第七天恢复至0.7。吲哚菁绿清除的这些下降先于总血清胆红素浓度升高至平均值1.9mg/dL。因此，吲哚菁绿清除被发现是肝功能受损的早期敏感指标。
