Schentag J J, O'Keeffe D, Marmion M, Wels P B
Arch Surg. 1984 Mar;119(3):300-4. doi: 10.1001/archsurg.1984.01390150040010.
C-reactive protein (CRP) concentrations were monitored serially in 97 patients with abdominal sepsis to determine if differences in infection type or site would produce diagnostic or prognostic CRP level elevations. After surgery and abdominal infection, the average (+/- SD) CRP peak values were 21.2 +/- 9.0 mg/dL. The CRP values rose markedly with infection, rose further with surgery, and subsided to less than 10 mg/dL with cure. Persistent levels of more than 10 mg/dL indicated abscess formation or continued infection. The average normal value at complete tissue healing after resolution of infection was 1.2 mg/dL, which was not different from that for healthy volunteers. Analysis suggested that CRP concentrations were not predictive of the type, site, or severity of abdominal infection; however, since persistent elevations were frequently associated with new or unresolved bacterial infection, serial determinations may be helpful in monitoring the course of disease and response to treatment.
对97例腹部脓毒症患者的C反应蛋白（CRP）浓度进行连续监测，以确定感染类型或部位的差异是否会导致诊断性或预后性CRP水平升高。手术和腹部感染后，CRP峰值的平均值（±标准差）为21.2±9.0mg/dL。CRP值随感染显著升高，随手术进一步升高，并在治愈后降至低于10mg/dL。持续高于10mg/dL的水平表明有脓肿形成或持续感染。感染消退后组织完全愈合时的平均正常值为1.2mg/dL，与健康志愿者的值无差异。分析表明，CRP浓度不能预测腹部感染的类型、部位或严重程度；然而，由于持续升高常与新的或未解决的细菌感染相关，连续测定可能有助于监测疾病进程和对治疗的反应。
