Hamilton T C, Fox H, Buckley C H, Henderson W J, Griffiths K
Br J Exp Pathol. 1984 Feb;65(1):101-6.
Exposure of rat ovaries to talc was accomplished by intrabursal injection. As early as 1 and up to 18 months after treatment, the ovaries and associated tissue were cystic in appearance; these changes were the result of bursal distention. Histologically the ovarian tissue was decreased in amount and spread as a remnant on the inner wall of the bursa. In four to 10 treated animals but in no controls, focal areas of papillary change were noted in the surface epithelium of the ovary. Polarized light and electron microscope microanalysis confirmed the presence of talc in the surface epithelium, ovarian cortex, and connective tissue matrix of the bursa. Although the changes in the ovarian surface may be related to direct effects of talc exposure, it is postulated that these changes might also be related to constant exposure to the high concentrations of steroid hormones which have undoubtedly accumulated in the intrabursal space.
通过囊内注射使大鼠卵巢暴露于滑石粉。早在治疗后1个月直至18个月，卵巢及相关组织外观呈囊性；这些变化是囊扩张的结果。组织学上，卵巢组织量减少，并作为残余物散布在囊内壁上。在4至10只接受治疗的动物中，但在对照组中未发现，卵巢表面上皮出现局灶性乳头样改变。偏光显微镜和电子显微镜微量分析证实滑石粉存在于卵巢表面上皮、卵巢皮质和囊的结缔组织基质中。虽然卵巢表面的变化可能与滑石粉暴露的直接影响有关，但据推测这些变化也可能与持续暴露于无疑已在囊内积聚的高浓度甾体激素有关。
