Mizukami Y, Matsubara F, Hashimoto T, Haratake J, Terahata S, Noguchi M, Hirose K
Cancer. 1984 Apr 15;53(8):1741-5. doi: 10.1002/1097-0142(19840415)53:8<1741::aid-cncr2820530821>3.0.co;2-c.
An extremely rare mucoepidermoid carcinoma of the thyroid gland was found in a 44-year-old woman. By light microscopic examination, the tumor consisted of mucous cells and squamoid cells, and was similar to that occurring in any other organs. By electron microscopic examination, the mucous cells displayed prominent mucous droplets, and showed no evidence of colloid production in their cytoplasms. Abundant tonofilaments in aggregates were observed in the squamoid cells. Biochemically, thyroxine (T4) and triiodothyronine (T3) were not detectable in the tissue of this tumor. These findings indicate that this mucoepidermoid carcinoma does not retain the functional properties of thyroid follicular cells; namely, no evidence was found to substantiate a follicular epithelial origin of this tumor.
一名44岁女性被发现患有极其罕见的甲状腺黏液表皮样癌。通过光镜检查，肿瘤由黏液细胞和鳞状细胞组成，与发生于其他任何器官的肿瘤相似。通过电镜检查，黏液细胞呈现出明显的黏液滴，其细胞质中未显示出产生胶体的迹象。在鳞状细胞中观察到大量聚集的张力丝。生化检查发现，该肿瘤组织中检测不到甲状腺素（T4）和三碘甲状腺原氨酸（T3）。这些发现表明，这种黏液表皮样癌不具备甲状腺滤泡细胞的功能特性；也就是说，未发现证据支持该肿瘤起源于滤泡上皮。
