Onoda N, Kang S M, Sugano S, Yamashita Y, Chung Y S, Sowa M
First Department of Surgery, Osaka City University Medical School, Japan.
Surg Today. 1995;25(9):843-7. doi: 10.1007/BF00311465.
We present herein the case of a 64-year-old man diagnosed as having a mucoepidermoid carcinoma of the pancreas. The tumor originated in the tail of the pancreas and invaded the spleen, left adrenal gland, left kidney, and transverse colon. Liver and peritoneal metastases were also noted. Despite surgical treatment and adjuvant chemotherapy, the disease progressed rapidly and the patient died of cachexia 4 months after his initial diagnosis. Mucoepidermoid carcinoma of the pancreas is a rare entity, and is believed to be a form of adenosquamous carcinoma known as adenoacanthoma. However, in this patient, no differentiated squamous cell component could be detected. In fact, the tumor was composed of mucin-producing cells, epidermoid cells, and intermediate cells. Immunohistochemical staining for the carcinoembryonic antigen, CA19-9, and SPan-1 demonstrated a production of cancerous mucin in the epidermoid cells, suggesting that mucoepidermoid carcinoma may arise from the squamoid metaplasia of an adenocarcinoma.
我们在此报告一例64岁男性，被诊断为胰腺黏液表皮样癌。肿瘤起源于胰尾，侵犯脾脏、左肾上腺、左肾和横结肠。同时也发现有肝转移和腹膜转移。尽管进行了手术治疗和辅助化疗，但疾病进展迅速，患者在初次诊断后4个月死于恶病质。胰腺黏液表皮样癌是一种罕见的实体瘤，被认为是腺棘皮瘤这一腺鳞癌的一种形式。然而，在该患者中，未检测到分化的鳞状细胞成分。实际上，肿瘤由产生黏液的细胞、表皮样细胞和中间细胞组成。癌胚抗原、CA19 - 9和SPan - 1的免疫组化染色显示表皮样细胞中有癌性黏液产生，提示黏液表皮样癌可能起源于腺癌的鳞状化生。
