Berardi R R, Hyneck M L, Cohen I A, Cornish L A, Achem S R
Clin Pharm. 1984 Jan-Feb;3(1):56-9.
The effect of cimetidine therapy on serum uric acid concentration was studied in four healthy men with normal renal function. Beginning four days before the 16-day study, subjects were permitted no beverages containing caffeine or alcohol and no medications and were placed on a weight-maintenance, isocaloric, purine-free 152-meq-sodium diet. On days 1-12 one cimetidine 300-mg tablet was taken four times daily; on days 13-16 no cimetidine was taken. On each study day, serum uric acid and creatinine and urine uric acid and creatinine concentrations were determined. Daily mean values for serum uric acid, total uric acid excreted, and uric acid clearance were not significantly different from baseline. No significant change occurred in creatinine excreted or creatinine clearance. Cimetidine administration to healthy men with normal renal function did not significantly affect serum uric acid concentration or renal clearance of urate.
在四名肾功能正常的健康男性中研究了西咪替丁治疗对血清尿酸浓度的影响。在为期16天的研究开始前四天，受试者不得饮用含咖啡因或酒精的饮料，不得服用任何药物，并采用维持体重、等热量、无嘌呤、152毫当量钠的饮食。在第1 - 12天，每天服用4次300毫克西咪替丁片剂；在第13 - 16天，不服用西咪替丁。在每个研究日，测定血清尿酸、肌酐以及尿尿酸和肌酐浓度。血清尿酸、总尿酸排泄量和尿酸清除率的每日平均值与基线无显著差异。肌酐排泄量或肌酐清除率无显著变化。对肾功能正常的健康男性给予西咪替丁不会显著影响血清尿酸浓度或尿酸的肾清除率。
