Globomycin, a new peptide antibiotic with spheroplast-forming activity. III. Structural determination of globomycin.
作者信息
Nakajima M, Inukai M, Haneishi T, Terahara A, Arai M, Kinoshita T, Tamura C
出版信息
J Antibiot (Tokyo). 1978 May;31(5):426-32. doi: 10.7164/antibiotics.31.426.
PMID:670085
Abstract
The structure of globomycin has been determined by mass, PMR and CMR spectra and by chemical degradation. Globomycin is a new cyclic peptide antibiotic composed of L-serine, L-allo-threonine, glycine, N-methylleucine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid. Among these components, L-allo-threonine, L-allo-isoleucine and 3-hydroxy-2-methylnonaic acid are novel components from natural products. A newly developed mass analysis has been introduced for determining the diastereoisomers of allo-threonine.
摘要
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