关于SF = 1902 A2 A5（SF - 1902的次要成分，球霉素）的研究。

Studies on SF=1902 A2 A5, minor components of SF-1902 (globomycin).

作者信息

Omoto S, Ogino H, Inouye S

出版信息

J Antibiot (Tokyo). 1981 Nov;34(11):1416-23. doi: 10.7164/antibiotics.34.1416.

DOI:10.7164/antibiotics.34.1416

PMID:7319905

Abstract

Four members of globomycin, SF-1902 A2, A3, A4a and A4b were newly isolated from the culture of Streptomyces hygroscopicus SF-1902. These minor components shared four amino acids in common and the fifth was either valine or allo-isoleucine. The fatty acid moiety varied from 3-hydroxy-2-methylheptanoic acid in A2 to 3-hydroxy-2-methylundecanoic acids in A4b. The length of alkyl chain greatly affected the antibacterial activity, and maximum activity was shown by the homologue (A5) possessing the longest alkyl chain.

摘要

从吸水链霉菌SF-1902的培养物中，新分离出了球霉素的四个成员，即SF-1902 A2、A3、A4a和A4b。这些次要成分共有四个相同的氨基酸，第五个氨基酸要么是缬氨酸，要么是别异亮氨酸。脂肪酸部分有所不同，从A2中的3-羟基-2-甲基庚酸到A4b中的3-羟基-2-甲基十一烷酸。烷基链的长度对抗菌活性有很大影响，具有最长烷基链的同系物（A5）表现出最大活性。