Ho K J, Jones J M, Herrera G A
South Med J. 1984 Feb;77(2):190-5. doi: 10.1097/00007611-198402000-00016.
Using light and electron microscopy, we recently studied a mucoepidermoid carcinoma of the larynx and reviewed 66 cases reported in the literature. Histologic features showed the origin of the tumor from the ductule of submucosal seromucous glands. The tumor was characterized by a mixed pattern of adenocarcinoma and squamous cell carcinoma. Six types of neoplastic cells were observed under the electron microscope, representing various stages of differentiation of the intermediate cells toward mucus-secreting, keratin-forming, and lumen-lining cells. The true incidence of this type of neoplasm could be higher than is believed because of its frequent misdiagnosis as squamous cell carcinoma. The importance of its differentiation from squamous cell carcinoma is emphasized because this tumor responds poorly to radiation therapy.
我们最近运用光镜和电镜研究了1例喉黏液表皮样癌，并复习了文献报道的66例病例。组织学特征显示肿瘤起源于黏膜下浆液黏液腺的小导管。肿瘤具有腺癌和鳞状细胞癌的混合模式。在电镜下观察到6种肿瘤细胞类型，代表中间细胞向黏液分泌细胞、角质形成细胞和腔面衬里细胞分化的不同阶段。由于这种肿瘤常被误诊为鳞状细胞癌，其实际发病率可能高于人们的认知。强调了将其与鳞状细胞癌鉴别诊断的重要性，因为该肿瘤对放射治疗反应较差。
