Roquefeuil B, Benezech J, Blanchet P, Batier C, Frerebeau P, Gros C
Surg Neurol. 1984 Feb;21(2):155-8. doi: 10.1016/0090-3019(84)90334-3.
Since February 1981, eight patients with neoplastic intractable pain have been treated by intracerebroventricular administration of small doses of morphine. Morphine was injected into the cerebrospinal fluid through a ventricular reservoir either by direct puncture or by self-administration. Clinical results were very good, and there were no deleterious effects.
自1981年2月以来，已有8例患有肿瘤顽固性疼痛的患者接受了脑室内注射小剂量吗啡的治疗。吗啡通过脑室储液器注入脑脊液，可直接穿刺注入，也可由患者自行给药。临床效果非常好，且无不良影响。
