Charreire J, Salamero J
Tissue Antigens. 1984 Jan;23(1):72-80. doi: 10.1111/j.1399-0039.1984.tb00012.x.
The determination of the frequency of normal spleen cell involvement in Primary syngeneic sensitization (PSS) against thyroid epithelial cells (TEC) was performed using the limiting dilution analysis. It was found that their frequency, which reaches 1:5440, is related to the expression of major histocompatibility complex (MHC) antigens (K end or D end) and of the specific antigen thyroglobulin (Tg) exposed on the surface of the TEC monolayer. Moreover, a significant diminution of this frequency was obtained by the addition of 25% normal syngeneic lymph node (LN) cells.
使用极限稀释分析法确定了针对甲状腺上皮细胞（TEC）的原发性同基因致敏（PSS）中正常脾细胞受累的频率。结果发现，其频率达到1:5440，这与主要组织相容性复合体（MHC）抗原（K端或D端）以及TEC单层表面暴露的特异性抗原甲状腺球蛋白（Tg）的表达有关。此外，通过添加25%的正常同基因淋巴结（LN）细胞，该频率显著降低。
