Salamero J, Charreire J
Immunol Lett. 1985;9(5):285-9. doi: 10.1016/0165-2478(85)90009-4.
We previously reported that the expression of Ia antigens on cultured monolayers of murine thyroid epithelial cells (TEC) occurred with a particular distribution exclusively on the basal part of the cultured thyroid cells, while class I antigens of the major histocompatibility complex (MHC) are only detected on the apical surface. It appears that deposition of syngeneic lymphocytes induces, 24 h later, Ia expression on the apical side of cultured TEC, the surface that is in direct contact with the responder lymphocytes during syngeneic sensitization of T lymphocytes. We hypothesized that this phenomenon could represent, in syngeneic situations, the restriction process in antigen recognition by T cells, as demonstrated by Ia restricted primary syngeneic sensitization (PSS) on murine TEC.
我们之前报道过，在培养的小鼠甲状腺上皮细胞（TEC）单层上，Ia抗原的表达呈现出特定分布，仅存在于培养的甲状腺细胞的基底部分，而主要组织相容性复合体（MHC）的I类抗原仅在顶端表面被检测到。似乎同基因淋巴细胞的沉积在24小时后会诱导培养的TEC顶端侧Ia表达，在T淋巴细胞同基因致敏过程中，该表面与反应性淋巴细胞直接接触。我们推测，在同基因情况下，这一现象可能代表T细胞抗原识别中的限制过程，正如在小鼠TEC上Ia限制的原发性同基因致敏（PSS）所证明的那样。
