Abou-Saleh M T, Merry J, Coppen A
Acta Psychiatr Scand. 1984 Feb;69(2):112-6. doi: 10.1111/j.1600-0447.1984.tb02473.x.
The hypothalamic-pituitary-adrenal function was investigated in alcoholic patients using the dexamethasone suppression test (DST). Seventy-two patients were studied when they had been abstinent from alcohol for 3 to 6 weeks. Eight patients undergoing detoxification and 79 control subjects were investigated for comparison. Alcoholic patients after a 3- to 6-week abstinence period showed significantly higher prevalence of abnormal DST results (28%) than control subjects (11%). Patients undergoing detoxification showed even a higher prevalence of abnormal DST results (62%). Abnormal DST status was not associated with the presence of depression in these patients but was associated with abnormal liver function. It is supposed that abnormal DST responses in alcoholic patients are not diagnostic of depression but appear to be related to effects of alcohol either on liver metabolism or on the hypothalamic-pituitary-adrenal function or both.
使用地塞米松抑制试验（DST）对酒精性患者的下丘脑 - 垂体 - 肾上腺功能进行了研究。72例患者在戒酒3至6周时接受了研究。另有8例正在进行解毒治疗的患者和79名对照受试者接受了调查以作比较。经过3至6周戒酒期的酒精性患者，其DST结果异常的患病率（28%）显著高于对照受试者（11%）。正在进行解毒治疗的患者DST结果异常的患病率甚至更高（62%）。DST状态异常与这些患者是否存在抑郁无关，但与肝功能异常有关。据推测，酒精性患者DST反应异常并非抑郁症的诊断依据，而是似乎与酒精对肝脏代谢或下丘脑 - 垂体 - 肾上腺功能或两者的影响有关。
