Balldin J, Berggren U, Bokström K, Lindstedt G, Sjöberg J, Wendestam C
Department of Psychiatry and Neurochemistry, University of Göteborg, Sweden.
Drug Alcohol Depend. 1992 Jun;30(2):175-9. doi: 10.1016/0376-8716(92)90023-6.
The relationship between dexamethasone suppression test (DST) response, depressive symptoms and liver function tests was investigated in 15 male alcohol-dependent patients for 2 weeks during alcohol withdrawal. Six of the patients relapsed into drinking within the investigation period. There was no association between DST response and relapse, which suggests that abnormal DST response has no predictive value for relapse into drinking. About 50% of the patients had abnormal DST responses during the first week of alcohol withdrawal. There was no relationship between DST response and depression or depressive symptoms. Depression remitted within 1-2 weeks, whereas DST responses remained abnormal for at least 2 weeks in 2 of the non-relapsing 9 patients. Abnormal DST response in alcohol withdrawal is unlikely to be due to alterations in liver function but may be attributable to the effect of alcohol on the hypothalamic-pituitary-adrenocortical axis.
在15名男性酒精依赖患者戒酒期间，对其进行了为期2周的地塞米松抑制试验（DST）反应、抑郁症状和肝功能检查之间关系的研究。其中6名患者在研究期间复发饮酒。DST反应与复发之间无关联，这表明异常的DST反应对饮酒复发无预测价值。约50%的患者在戒酒第一周出现异常的DST反应。DST反应与抑郁或抑郁症状之间无关系。抑郁在1 - 2周内缓解，而在9名未复发的患者中，有2名患者的DST反应至少持续2周异常。戒酒时DST反应异常不太可能是由于肝功能改变，而可能归因于酒精对下丘脑 - 垂体 - 肾上腺皮质轴的影响。
