Kane M L, Ladov E N, Holdsworth C E, Weaver N K
Am J Ind Med. 1984;5(3):183-200. doi: 10.1002/ajim.4700050304.
In the past, reports on the tumorigenic potential of lubricating oils in experimental animals have poorly defined the materials under study. In this paper the results of mouse skin painting studies with 46 clearly defined samples of refinery streams associated with lubricating oil processing show that modern conventional solvent refining of distillates removes tumorigenic potential while conventional acid refining may not. Furthermore, dewaxing, hydrofinishing, and clay treatments do not appear to mitigate the tumorigenicity of the lubricant distillates. Lubricant processing has changed over the years and assessments of the carcinogenicity of present-day lubricating materials must be based on knowledge of modern processing.
过去，关于润滑油在实验动物体内致瘤潜力的报告对所研究的材料定义不清。本文对46个与润滑油加工相关的炼油厂馏分油明确样本进行小鼠皮肤涂抹研究的结果表明，现代常规的馏分油溶剂精制可消除致瘤潜力，而常规酸精制可能无法做到。此外，脱蜡、加氢精制和白土处理似乎无法减轻润滑油馏分油的致瘤性。多年来润滑油加工工艺已发生变化，对当今润滑材料致癌性的评估必须基于对现代加工工艺的了解。
