Halder C A, Warne T M, Little R Q, Garvin P J
Am J Ind Med. 1984;5(4):265-74. doi: 10.1002/ajim.4700050403.
Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were evaluated in standard mouse skin-painting bioassays. The refining process used as well as the level or severity of treatment greatly influenced the carcinogenic outcome of processed lubricating oils. Solvent refining at severities normally used appeared to eliminate carcinogenicity. In contrast, hydroprocessing alone at mild levels of treatment was successful only in reducing the carcinogenic potency; severe hydroprocessing conditions were necessary to eliminate carcinogenic activity without the use of additional refining processes. Carcinogenic activity could also be eliminated by following moderate solvent refining with mild hydroprocessing. Blending of hydroprocessed oils with solvent-refined oils resulted in a substantial reduction or even elimination of carcinogenic activity. However, the degree of protection obtained varied with the particular distillates used and appeared largely dependent on the inherent biological activity of the hydroprocessed oil.
研究了某些精炼工艺，以确定它们对石油衍生润滑油馏分的皮肤致癌活性的影响。具体而言，在标准的小鼠皮肤涂抹生物测定中评估了溶剂精制、加氢处理、这两种工艺的组合以及使用每种技术加工的油的混合效果。所使用的精炼工艺以及处理的程度或强度极大地影响了加工后润滑油的致癌结果。通常使用的强度下进行溶剂精制似乎可以消除致癌性。相比之下，仅在温和处理水平下进行加氢处理仅能成功降低致癌效力；在不使用额外精炼工艺的情况下，需要严格的加氢处理条件才能消除致癌活性。通过先进行适度的溶剂精制再进行温和的加氢处理，也可以消除致癌活性。将加氢处理的油与溶剂精制的油混合可大幅降低甚至消除致癌活性。然而，所获得的保护程度因所使用的特定馏分而异，并且似乎很大程度上取决于加氢处理油的固有生物活性。
