McKee R H, Scala R A, Chauzy C
Exxon Biomedical Sciences, Inc., East Millstone, NJ.
J Appl Toxicol. 1990 Aug;10(4):251-6. doi: 10.1002/jat.2550100405.
Epidermal cancer in humans has been associated with industrial exposure to products derived from unrefined petroleum distillates. Because of this association many of these products, including cutting fluids, are now normally produced from highly refined lubricant base oils. Since highly refined oils are not dermally carcinogenic, one would predict that formulated products prepared from these oils would similarly be non-tumorigenic. However, there are experimental data that suggest that fresh cutting fluids might be dermally carcinogenic and that industrial usage might increase the carcinogenic hazard. The current studies evaluated solvent-extracted lubricant base oils and several products, including fresh and used cutting fluids and certain related industrial oils. These materials were all tested for tumorigenic potential in mouse epidermal carcinogenesis bioassays. None of the solvent-extracted lubricant base oils were dermal carcinogens. Similarly, the cutting fluids and industrial oils formulated from these base oils were not dermally carcinogenic. Finally, there was no evidence that industrial usage influenced the carcinogenic potential of these oils. It was concluded that solvent-extracted oils and the products derived from these oils pose minimal skin cancer hazards when used under appropriate conditions in industrial settings.
人类的表皮癌与工业接触未精炼石油馏出物衍生的产品有关。由于这种关联，现在许多此类产品，包括切削液，通常由高度精炼的润滑油基础油生产。由于高度精炼的油不会引起皮肤致癌，因此可以预测由这些油制备的配方产品同样不会致癌。然而，有实验数据表明，新鲜切削液可能具有皮肤致癌性，工业使用可能会增加致癌风险。当前的研究评估了溶剂萃取的润滑油基础油以及几种产品，包括新鲜和使用过的切削液以及某些相关工业用油。这些材料均在小鼠表皮致癌生物测定中测试了致癌潜力。没有一种溶剂萃取的润滑油基础油是皮肤致癌物。同样，由这些基础油配制的切削液和工业用油也没有皮肤致癌性。最后，没有证据表明工业使用会影响这些油的致癌潜力。得出的结论是，溶剂萃取油及其衍生产品在工业环境中适当条件下使用时，对皮肤癌的危害极小。
