Bradsher R W
Am Rev Respir Dis. 1984 Mar;129(3):430-4. doi: 10.1164/arrd.1984.129.3.430.
The development of specific cellular-immune mechanisms has not been reported in human blastomycosis. We have examined lymphocyte stimulation to a fungal antigen before and during antifungal therapy in 16 patients with blastomycosis. Patients with pulmonary infection only did not have increased 3H-thymidine uptake on initial testing, but all 8 had vigorous lymphocyte stimulation as an indicator of cellular immunity after at least 2 wk of therapy. Patients with extrapulmonary blastomycosis had higher counts in response to the Blastomyces antigen before therapy. These tests differentiated between those with blastomycosis after therapy was started and normal persons or those with a nonfungal infection. Because of the delayed appearance, lymphocyte stimulation does not appear helpful for diagnosis of persons with untreated pulmonary blastomycosis, but in vitro correlates of cellular immunity developed in these patients in a similar time course as with other chronic infections.
人类芽生菌病中尚未报道特异性细胞免疫机制的发展情况。我们检测了16例芽生菌病患者在抗真菌治疗前及治疗期间对真菌抗原的淋巴细胞刺激反应。仅患有肺部感染的患者在初始检测时3H-胸腺嘧啶核苷摄取未增加，但所有8例患者在治疗至少2周后均有强烈的淋巴细胞刺激反应，作为细胞免疫的指标。肺外芽生菌病患者在治疗前对芽生菌抗原的反应计数较高。这些检测区分了开始治疗后的芽生菌病患者与正常人和非真菌感染患者。由于淋巴细胞刺激反应出现延迟，其似乎对未治疗的肺部芽生菌病患者的诊断没有帮助，但这些患者体内细胞免疫的体外相关性与其他慢性感染在相似的时间进程中发展。
