Sytnik I A
Antibiotiki. 1984 Feb;29(2):95-9.
Sensitivity of staphylococci of different origin to desoxycholic, cholic and choleic bile acids was studied. On this basis a system for differentiation of the staphylococcal bilicultures from the staphylococcal cultures of the other origin was developed. It was shown that the bile and bile acids potentiated the activity of some antibiotics and inhibited the action of the others. Such a strictly individual property of synergism or antagonism of the cholates and antibiotics depended on the properties of the causative agent and the type of the antibiotics and bile acids. The results of the study provided the development of a method for determination of the biliculture antibiotic sensitivity on a medium containing the patient's bile. The antibiotic which induced the maximum inhibition of the bacterial growth in the presence of the patient's bile should be recommended for the treatment of this patient.
研究了不同来源的葡萄球菌对脱氧胆酸、胆酸和鹅胆酸的敏感性。在此基础上，建立了一种从其他来源的葡萄球菌培养物中区分葡萄球菌胆汁培养物的系统。结果表明，胆汁和胆汁酸可增强某些抗生素的活性，同时抑制其他抗生素的作用。胆酸盐与抗生素协同或拮抗的这种严格的个体特性取决于病原体的特性以及抗生素和胆汁酸的类型。该研究结果为开发一种在含有患者胆汁的培养基上测定胆汁培养物抗生素敏感性的方法提供了依据。对于该患者的治疗，应推荐在患者胆汁存在时能最大程度抑制细菌生长的抗生素。
