Sytnik I A, Andreĭchin M A, Kalashnik S A
Antibiotiki. 1978 Jul;23(7):600-5.
It was found in vitro that desoxycholic, cholic, glycocholic and choleinic acids inhibited the growth and development of staphylococci. The staphylococci isolated from bile were more resistant to the bacteriostatic and bactericidal effect of bile acids than the microorganisms isolated from other sources not containing cholates. Under the effect of these substances the activity of some antibiotics especially those from the group of aminoglycosides markedly increased.
体外实验发现，脱氧胆酸、胆酸、甘胆酸和鹅胆酸可抑制葡萄球菌的生长和发育。从胆汁中分离出的葡萄球菌比从不含胆酸盐的其他来源分离出的微生物对胆汁酸的抑菌和杀菌作用更具抗性。在这些物质的作用下，某些抗生素尤其是氨基糖苷类抗生素的活性显著增强。
