Bandmann U, Bäck O, Norberg B
Arch Dermatol Res. 1984;276(1):41-4. doi: 10.1007/BF00412561.
In a previous study, polymorphonuclear (PMN) leukocyte chemotaxis in vitro was inhibited by therapeutic concentrations of griseofulvin. In the present investigation, PMN migration in a casein gradient was studied in a cell suspension containing serum collected before and after a therapeutic peroral single-dose of griseofulvin. The PMN migration in vitro was not influenced significantly by the presence of griseofulvin-containing serum. It is suggested that peroral griseofulvin treatment has negligible effect on PMN chemotaxis in vitro.
在先前的一项研究中，治疗浓度的灰黄霉素可抑制体外多形核（PMN）白细胞趋化性。在本研究中，在含有口服单剂量治疗性灰黄霉素前后采集的血清的细胞悬液中，研究了酪蛋白梯度中的PMN迁移。含灰黄霉素血清的存在对体外PMN迁移没有显著影响。提示口服灰黄霉素治疗对体外PMN趋化性的影响可忽略不计。
