Takigawa M, Miyachi Y, Uehara M, Tagami H
Arch Dermatol. 1982 Jul;118(7):458-60.
The effect of oral doses of colchicine on pustule formation was studied in 32 patients with pustulosis palmaris et plantaris without associated psoriasis. Oral administration of colchicine, 1 to 2 mg daily, was started during periods of disease exacerbation, and the dosage was gradually decreased to 0.5 to 1 mg daily in responsive patients. Thirteen patients showed complete clearing of pustulation, and 14 patients showed a remarkable reduction in pustule formation after two to eight weeks of treatment. One patient did not respond and four discontinued treatment because of nausea or diarrhea. During a three-month follow-up evaluation after treatment was stopped, relapse occurred in eight cases. Colchicine appears to be effective in the suppression of acute exacerbations of pustulosis palmaris et plantaris.
对32例无相关银屑病的掌跖脓疱病患者研究了口服秋水仙碱对脓疱形成的影响。在疾病加重期开始每日口服1至2毫克秋水仙碱，对于有反应的患者，剂量逐渐减至每日0.5至1毫克。13例患者脓疱完全消退，14例患者在治疗两至八周后脓疱形成明显减少。1例患者无反应，4例因恶心或腹泻而中断治疗。在停止治疗后的三个月随访评估中，8例出现复发。秋水仙碱似乎对抑制掌跖脓疱病的急性加重有效。
