Warnold I, Lundholm K
Ann Surg. 1984 Mar;199(3):299-305. doi: 10.1097/00000658-198403000-00009.
Preoperative nutritional status was assessed by: the percentage weight loss (% WL), body weight in relation to reference weight (WI), arm muscle circumference (AMC), and S-albumin (S-Alb) in a prospective study of 215 noncancer patients classified into three groups according to type of surgery: major vascular, minor vascular, and abdominal. The clinical significance of the nutritional markers was assessed by correlations to postoperative outcome and the time spent in the hospital after surgery. The influence of age on nutritional markers and clinical variables was evident but was ruled out in all correlations. If malnutrition was classified as two or more abnormal values in the nutritional markers (% WL, WI, AMC, S-Alb), the overall frequency was 12%, highest in the major vascular surgery group (18%) and lowest in the minor vascular group (4%). Patients with low nutritional status stayed an average of 29 days in the hospital compared to 14 days if the nutritional status was normal (p less than 0.01). The overall complication frequency was higher in patients with low nutritional status compared to normal status (48% and 23%, respectively, p less than 0.01). The frequency of serious complications was 31% in undernourished and 9% in well-nourished patients (p less than 0.05). Various nonnutritional variables such as age, diagnosis, and duration of surgery were shown to increase the predictive ability of nutritional status. The results of this study confirm that nutritional state per se is predictive for postoperative outcome even when variables were stabilized for different backgrounds with covariation to nutritional status.
在一项对215名非癌症患者的前瞻性研究中,根据手术类型将其分为三组:大血管手术组、小血管手术组和腹部手术组,通过以下指标评估术前营养状况:体重减轻百分比(%WL)、相对于参考体重的体重(WI)、上臂肌肉围(AMC)和血清白蛋白(S-Alb)。通过与术后结果及术后住院时间的相关性评估营养标志物的临床意义。年龄对营养标志物和临床变量的影响很明显,但在所有相关性分析中都被排除。如果将营养不良定义为营养标志物(%WL、WI、AMC、S-Alb)中有两个或更多异常值,则总体发生率为12%,在大血管手术组中最高(18%),在小血管手术组中最低(4%)。营养状况差的患者平均住院29天,而营养状况正常的患者平均住院14天(p<0.01)。营养状况差的患者总体并发症发生率高于营养状况正常的患者(分别为48%和23%,p<0.01)。营养不良患者严重并发症的发生率为31%,营养良好患者为9%(p<0.05)。年龄、诊断和手术时长等各种非营养变量显示可提高营养状况的预测能力。本研究结果证实,即使在对不同背景的变量进行稳定化处理并与营养状况进行协变量分析后,营养状态本身仍可预测术后结果。