Hsu H T, Dorey K, Sorgente N, Ryan S J
Arch Ophthalmol. 1984 Apr;102(4):605-7. doi: 10.1001/archopht.1984.01040030477030.
The effect of surgical removal of vitreous on intraocular fibroblast proliferation was studied in an animal model. Forty-eight young adult pigmented rabbits were vitrectomized; four groups of eight animals subsequently received intravitreal injection of tissue-cultured rabbit dermal fibroblasts in doses of 50,000, 100,000, 250,000, and 750,000 cells. As controls, eight vitrectomized rabbits received intravitreal culture medium alone, and the remaining eight vitrectomized rabbits were left uninjected. An additional 40 normal rabbits received the same injections of the same four doses and served as nonvitrectomized controls. All animals were observed for 28 days after injection. The results were dose related and showed that vitrectomy aggravated intraocular fibroblast proliferation in that traction retinal detachment occurred earlier and was more severe in the vitrectomized than in the nonvitrectomized controls.
在动物模型中研究了手术切除玻璃体对眼内成纤维细胞增殖的影响。对48只成年有色青年兔进行了玻璃体切除术；随后，四组每组8只动物接受玻璃体内注射组织培养的兔真皮成纤维细胞，剂量分别为50000、100000、250000和750000个细胞。作为对照，8只接受玻璃体切除术的兔子仅接受玻璃体内培养基注射，其余8只接受玻璃体切除术的兔子未注射。另外40只正常兔子接受相同的四剂相同注射，作为未接受玻璃体切除术的对照。注射后对所有动物观察28天。结果与剂量相关，表明玻璃体切除术加剧了眼内成纤维细胞增殖，因为与未接受玻璃体切除术的对照相比，接受玻璃体切除术的兔子发生牵引性视网膜脱离更早且更严重。
