化脓性脑膜炎中的一种脑脊液白细胞毒素

A cerebrospinal fluid leucocidin in pyogenic meningitis.

作者信息

Greenwood B M

出版信息

J Clin Pathol. 1978 Jul;31(7):688-91. doi: 10.1136/jcp.31.7.688.

DOI:10.1136/jcp.31.7.688

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1145375/

Abstract

Cerebrospinal fluid (CSF) samples were tested for their cytotoxicity to polymorphonuclear neutrophil leucocytes (PMN) using a 51Cr release assay. Most samples from patients with pyogenic meningitis damaged PMN while normal CSF samples did not. No difference was found between the cytotoxic activity of CSF from patients with pneumococcal meningitis and from patients with meningococcal meningitis. It is, therefore, unlikely that a CSF leucocidin plays an important part in producing the high mortality of pneumococcal meningitis.

摘要

使用51Cr释放试验检测脑脊液（CSF）样本对多形核中性粒细胞（PMN）的细胞毒性。大多数化脓性脑膜炎患者的样本会损伤PMN，而正常脑脊液样本则不会。肺炎球菌性脑膜炎患者的脑脊液与脑膜炎球菌性脑膜炎患者的脑脊液细胞毒性活性之间未发现差异。因此，脑脊液白细胞毒素在导致肺炎球菌性脑膜炎的高死亡率方面不太可能起重要作用。

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本文引用的文献

1

Neutrophil granulocyte function in bacterial infections.中性粒细胞在细菌感染中的功能。

Lancet. 1972 Oct 7;2(7780):727-30. doi: 10.1016/s0140-6736(72)92022-3.

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Pneumococcal meningitis: a clinical and laboratory study.

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Chemotactic activity of cerebrospinal fluid in pyogenic meningitis.

J Clin Pathol. 1978 Mar;31(3):213-6. doi: 10.1136/jcp.31.3.213.

4

Bacteriolytic activity of normal and pathological cerebrospinal fluid.

Acta Pathol Microbiol Scand C. 1977 Feb;85(1):21-5. doi: 10.1111/j.1699-0463.1977.tb03606.x.

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