Greenwood B M
J Clin Pathol. 1978 Jul;31(7):688-91. doi: 10.1136/jcp.31.7.688.
Cerebrospinal fluid (CSF) samples were tested for their cytotoxicity to polymorphonuclear neutrophil leucocytes (PMN) using a 51Cr release assay. Most samples from patients with pyogenic meningitis damaged PMN while normal CSF samples did not. No difference was found between the cytotoxic activity of CSF from patients with pneumococcal meningitis and from patients with meningococcal meningitis. It is, therefore, unlikely that a CSF leucocidin plays an important part in producing the high mortality of pneumococcal meningitis.
使用51Cr释放试验检测脑脊液（CSF）样本对多形核中性粒细胞（PMN）的细胞毒性。大多数化脓性脑膜炎患者的样本会损伤PMN，而正常脑脊液样本则不会。肺炎球菌性脑膜炎患者的脑脊液与脑膜炎球菌性脑膜炎患者的脑脊液细胞毒性活性之间未发现差异。因此，脑脊液白细胞毒素在导致肺炎球菌性脑膜炎的高死亡率方面不太可能起重要作用。
