脑脊液对脑膜炎球菌和肺炎球菌生长的抑制作用。

Inhibitory effect of cerebrospinal fluid on the growth of meningococci and pneumococci.

作者信息

Hassan-King M, Whittle H C, Greenwood B M

出版信息

J Clin Pathol. 1984 Apr;37(4):428-32. doi: 10.1136/jcp.37.4.428.

DOI:10.1136/jcp.37.4.428

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC498745/

Abstract

Initial cerebrospinal fluid (CSF) samples obtained from patients with pneumococcal meningitis usually contain far greater numbers of bacteria than initial CSF samples obtained from patients with meningococcal meningitis. Normal CSF was found to have an inhibitory effect on the growth of group A meningococci but not on type 1 pneumococci. The inhibitory effect of normal CSF was abolished by dialysis, indicating that the inhibitory factor has a low molecular weight. Heating normal CSF to 62.5 degrees C for 30 min resulted in a considerable reduction in the inhibitory effect, indicating that the inhibitory factor is heat labile.

摘要

从肺炎球菌性脑膜炎患者获得的初始脑脊液（CSF）样本通常比从脑膜炎球菌性脑膜炎患者获得的初始脑脊液样本含有更多的细菌。发现正常脑脊液对A群脑膜炎球菌的生长有抑制作用，但对1型肺炎球菌没有抑制作用。正常脑脊液的抑制作用通过透析被消除，这表明抑制因子分子量较低。将正常脑脊液加热到62.5摄氏度30分钟导致抑制作用显著降低，这表明抑制因子对热不稳定。

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本文引用的文献

1

Chemical analysis of spectrophotometric findings in the cerebrospinal fluid.脑脊液分光光度测定结果的化学分析。

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Lancet. 1974 Sep 14;2(7881):619-21. doi: 10.1016/s0140-6736(74)91943-6.

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Counter-current immunoelectrophoresis in the diagnosis of meningococcal infections.对流免疫电泳在脑膜炎球菌感染诊断中的应用

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A cerebrospinal fluid leucocidin in pyogenic meningitis.化脓性脑膜炎中的一种脑脊液白细胞毒素

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