Hassan-King M, Whittle H C, Greenwood B M
J Clin Pathol. 1984 Apr;37(4):428-32. doi: 10.1136/jcp.37.4.428.
Initial cerebrospinal fluid (CSF) samples obtained from patients with pneumococcal meningitis usually contain far greater numbers of bacteria than initial CSF samples obtained from patients with meningococcal meningitis. Normal CSF was found to have an inhibitory effect on the growth of group A meningococci but not on type 1 pneumococci. The inhibitory effect of normal CSF was abolished by dialysis, indicating that the inhibitory factor has a low molecular weight. Heating normal CSF to 62.5 degrees C for 30 min resulted in a considerable reduction in the inhibitory effect, indicating that the inhibitory factor is heat labile.
从肺炎球菌性脑膜炎患者获得的初始脑脊液（CSF）样本通常比从脑膜炎球菌性脑膜炎患者获得的初始脑脊液样本含有更多的细菌。发现正常脑脊液对A群脑膜炎球菌的生长有抑制作用，但对1型肺炎球菌没有抑制作用。正常脑脊液的抑制作用通过透析被消除，这表明抑制因子分子量较低。将正常脑脊液加热到62.5摄氏度30分钟导致抑制作用显著降低，这表明抑制因子对热不稳定。
