Luboshitzky R, Tal-Or Z, Barzilai D
J Clin Pharmacol. 1978 Jul;18(7):336-9. doi: 10.1002/j.1552-4604.1978.tb01602.x.
A 60-year-old woman who had been instructed to increase her water intake because of nephrolithiasis developed the syndrome of inappropriate secretion of antidiuretic hormone when treated with chlorthalidone for mild hypertension. Serum osmolality was 235 mOsm/kg with concomitant urine osmolality of 490 mOsm/kg. When serum sodium decreased to 110 mEq/liter, plasma antidiuretic hormone (ADH) was elevated at 30 pg/ml. The syndrome resolved when chlorthalidone was discontinued together with fluid intake restriction. Plasma ADH returned to normal (less than 0.5 pg/ml) after three days of treatment. The favorable outcome in this patient is attributed to early recognition of the syndrome, which might occur even with nonthiazide diuretics such as chlorthalidone.
一名60岁女性因肾结石被要求增加饮水量，在使用氯噻酮治疗轻度高血压时发生了抗利尿激素分泌不当综合征。血清渗透压为235 mOsm/kg，同时尿渗透压为490 mOsm/kg。当血清钠降至110 mEq/升时，血浆抗利尿激素（ADH）升高至30 pg/ml。停用氯噻酮并限制液体摄入后，该综合征得以缓解。治疗三天后，血浆ADH恢复正常（低于0.5 pg/ml）。该患者的良好预后归因于对该综合征的早期识别，即使使用氯噻酮等非噻嗪类利尿剂也可能发生这种情况。
