缺血后无钙再灌注对去甲肾上腺素及其代谢产物的洗脱：对缺血诱导去甲肾上腺素释放概念的支持
Wash-out of noradrenaline and its metabolites by calcium-free reperfusion after ischaemia: support for the concept of ischaemia-induced noradrenaline release.
作者信息
Abrahamsson T, Almgren O, Carlsson L
出版信息
Br J Pharmacol. 1984 Jan;81(1):22-4. doi: 10.1111/j.1476-5381.1984.tb10738.x.
Abstract
The outflow of noradrenaline (NA) and its metabolites on reperfusion after 60 min of regional ischaemia in the isolated heart of the rat was not diminished when calcium was omitted from the reperfusion medium. The findings suggest a release of NA during ischaemia, washed-out at reperfusion.
摘要
在大鼠离体心脏局部缺血60分钟后再灌注时，若再灌注培养基中不含钙，去甲肾上腺素（NA）及其代谢产物的流出并未减少。这些发现提示在缺血期间有NA释放，并在再灌注时被洗脱。
相似文献
1
Wash-out of noradrenaline and its metabolites by calcium-free reperfusion after ischaemia: support for the concept of ischaemia-induced noradrenaline release.缺血后无钙再灌注对去甲肾上腺素及其代谢产物的洗脱：对缺血诱导去甲肾上腺素释放概念的支持
Br J Pharmacol. 1984 Jan;81(1):22-4. doi: 10.1111/j.1476-5381.1984.tb10738.x.
2
Metabolic requirements for release of endogenous noradrenaline during myocardial ischaemia and anoxia.心肌缺血和缺氧期间内源性去甲肾上腺素释放的代谢需求。
Br J Pharmacol. 1987 Jan;90(1):43-50. doi: 10.1111/j.1476-5381.1987.tb16823.x.
3
Ischaemia-induced release of noradrenaline and creatine kinase in the isolated, working rat heart.缺血诱导的去甲肾上腺素和肌酸激酶在离体工作大鼠心脏中的释放。
Acta Physiol Scand. 1987 May;130(1):83-93. doi: 10.1111/j.1748-1716.1987.tb08115.x.
4
Reduced neuronal noradrenaline overflow in the ischaemic rat heart: importance of the severity of coronary flow reduction.缺血大鼠心脏中神经元去甲肾上腺素溢出减少：冠状动脉血流减少严重程度的重要性。
Basic Res Cardiol. 1991 Jan-Feb;86(1):11-20. doi: 10.1007/BF02193867.
5
Ischemia-induced noradrenaline release in the isolated rat heart: influence of perfusion substrate and duration of ischemia.缺血诱导的离体大鼠心脏去甲肾上腺素释放：灌注底物和缺血持续时间的影响。
J Mol Cell Cardiol. 1983 Dec;15(12):821-9. doi: 10.1016/0022-2828(83)90344-9.
6
Ischemia-induced local release of myocardial noradrenaline.缺血诱导的心肌去甲肾上腺素局部释放。
J Cardiovasc Pharmacol. 1985;7 Suppl 5:S19-22. doi: 10.1097/00005344-198500075-00005.
7
Origins of endogenous noradrenaline overflow during reperfusion of the ischaemic rat heart.缺血大鼠心脏再灌注期间内源性去甲肾上腺素溢出的起源
Clin Sci (Lond). 1988 Mar;74(3):269-74. doi: 10.1042/cs0740269.
8
Calcium antagonists and the ischaemic myocardium.钙拮抗剂与缺血心肌
Eur Heart J. 1986 Jul;7 Suppl B:27-34. doi: 10.1093/eurheartj/7.suppl_b.27.
9
Release of noradrenaline in myocardial ischemia--importance of local inactivation by neuronal and extraneuronal mechanisms.心肌缺血时去甲肾上腺素的释放——神经元和非神经元机制局部失活的重要性。
J Cardiovasc Pharmacol. 1986 May-Jun;8(3):545-53. doi: 10.1097/00005344-198605000-00017.
引用本文的文献
1
Relation between energy metabolism, glycolysis, noradrenaline release and duration of ischemia.能量代谢、糖酵解、去甲肾上腺素释放与缺血持续时间之间的关系。
Mol Cell Biochem. 1996 Jul-Aug;160-161:187-94. doi: 10.1007/BF00240049.
2
Early intraneuronal mobilization and deamination of noradrenaline during global ischemia in the isolated perfused rat heart.离体灌注大鼠心脏在全心缺血期间去甲肾上腺素的早期神经元内动员与脱氨基作用
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):508-18. doi: 10.1007/BF00169307.
本文引用的文献
1
Low calcium reperfusion of ischemic myocardium.缺血心肌的低钙再灌注。
J Mol Cell Cardiol. 1983 Apr;15(4):251-60. doi: 10.1016/0022-2828(83)90280-8.
2
Cation dependence of sympathetic transmitter retention by slices of rat ventricle.大鼠心室切片对交感神经递质保留的阳离子依赖性
Br J Pharmacol Chemother. 1967 Mar;29(3):309-18. doi: 10.1111/j.1476-5381.1967.tb01962.x.
3
The effects of inorganic ions on the storage and uptake of H3-norepinephrine by rat heart slices.无机离子对大鼠心脏切片储存和摄取H3-去甲肾上腺素的影响。
J Pharmacol Exp Ther. 1969 Feb;165(2):181-9.
4
The oxygen paradox and the calcium paradox: two facets of the same problem?氧悖论与钙悖论：同一问题的两个方面？
J Mol Cell Cardiol. 1978 Jul;10(7):641-68. doi: 10.1016/s0022-2828(78)80004-2.
Zotero 插件